The Meridian Railroad Museum is located in the heart of Downtown Meridian, Mississippi right along the Meridian Speedway. The Meridian Railroad Museum is housed in the former freight station and Railway Express Agency building adjacent to the Meridian Union Station and the Norfolk Southern mainline. Built in 1906 in the Mission Revival style, the station and freight house served a variety of fallen flag passenger trains throughout the 20th century, including the Gulf, Mobile & Ohio, the Illinois Central, and the Southern Railway. The museum includes a trio of retired rolling stock, including a caboose from the nearby Meridian & Bigbee shortline. The building is listed on the National Register of Historic Places.

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Meridian Rails Historical Society took possession of the building in November of 2021 when the Meridian City Council voted to donate the building to the society for usage of a permanent home for the railroad museum.